Laser enrichment,invented in America

LIS Technologies is developing CRISLA, a patented U.S.-origin laser process for enriching uranium and stable isotopes, in Oak Ridge, Tennessee.

Explore CRISLA Our Oak Ridge sites

5.3 µmContinuous-wave CO laser

Low-enriched uraniumHALEU for advanced reactorsSilicon-28Medical isotopesQuantum materialsContinuous-wave CO laserOak Ridge, Tennessee Low-enriched uraniumHALEU for advanced reactorsSilicon-28Medical isotopesQuantum materialsContinuous-wave CO laserOak Ridge, Tennessee

The CRISLA process

One laser, tuned to a single isotope

CRISLA uses infrared light to excite only the molecules of the isotope we want. Excited uranium-235 is kept from condensing in a supersonic jet, so the isotopes leave in separate streams. First shown in 1993, it is now being re-demonstrated in our Oak Ridge test loop.

How CRISLA works Our patent

Aerial view of the forested hills of Oak Ridge, Tennessee

LIS Technologies sign on the K-1330 building

Our headquarters and Demonstration Test Loop Facility are in the K-1330 building, Oak Ridge.

Markets

Fuel for reactors. Isotopes for medicine and chips.

One laser platform, two markets: enriched uranium for nuclear power and stable isotopes for medicine, semiconductors and quantum.

Nuclear fuel

Enriched uranium for today's reactors and the next generation

Low-enriched uranium for the existing fleet, and HALEU for small modular and advanced reactors.

Scientists in a cleanroom inspecting a silicon sample

Project SMILE

Stable and medical isotopes, starting with silicon-28

Why lasers

Built for selectivity

6.7: Enrichment factor per stage, 1993 demonstration
1.004: Per stage for gaseous diffusion
100%: Continuous duty cycle, no pulses

Clean industrial process facility interior

Project FUEL

From test loop to industrial scale

A Pilot Plant targeted around 2030, then an LEU-3 facility of up to 5.0 million SWU a year.

Oak Ridge, Tennessee

Laser enrichment, back at K-25

Our sites sit on the footprint of the K-25 gaseous diffusion plant, built for the Manhattan Project in the 1940s.

Grand opening of the LIST facility at K-1330

K-1330Headquarters and Demonstration Test Loop FacilityFirst UF6 in 2026
K-158037,800 sq ft for isotope and fuel cycle workPurchased 2026
LIST Island206 acres planned for Project FUELAcquired 2026

LIST at a glance

Progress you can measure

206

Acres on LIST Island, acquired January 2026

2019

U.S. patent issued for CRISLA, now assigned to LIST

TRL 4

Independent technology readiness assessment, March 2025

37,800

Square feet at K-1580 for isotope and fuel cycle work

Enriching the future

Let's talk about fuel and isotopes

Utilities, reactor developers and isotope users can reach our team in Oak Ridge.

Contact our team Careers at LIST